Premoves are especially useful for bullet/lightning, but I think they are very dangerous in the opening if you simply trust the opponent to play theory. A clever opponent could anti-premove you:swami wrote: for openings and winning endings pre-moving is easier.
1.e4 e5 2.Nf3 a6
I think once I won a queen similar to this, against a 'furiously' premoving opponent: 1. e4 c5 2. Nf3 d6 3. d4 cxd4 4. Nxd4 Bg4 5. Nc3 Bxd1
I use only 'safe' premoves, for recapturing moves if I can expect a capturing move. This bears no risk. For example, in the Ruy Lopez after 3...a6, I can enter d7xc6 as a premove, which can only happen if White plays Bxc6. Another occasion (less safe) is if the opponent practically must make a specific move, like the only move to recapture something. Although he could do something else if he is crazy enough. So I use it only if I want to put time pressure on him, and usually not in rated games, in such situations.
But the recapture-premoves are no problem. If the opponent plays something else, they simply disappear.
